Preliminary intravenous injections of donkeys of solution of Picric Acid in water and alcohol proved that up to 5 grammes of Picric Acid could be administered, but with the production of toxic symptoms, there being colic, micturition, frequent defecation, diarrhoea, and patchy sweating.

Loss of co-ordination was seen in all cases, but this was due to to the alcohol used as solvent for the Picric Acid.

The following were the strengths of the solutions injected : Picric Acid-aqueous solution —, 1 in 90. Picric Acid-alcoholic solution — 1 in 15. Tartar Emetic was 2% aqueous solution for equines and 4% aqueous solution for camels.

Five cases of Trypanosomiasis were subjected to treatment as follows Case (i).

Bay Sudan Country-bred horse (No. 101), 13.2, 16 years old-A naturally infected case of Trypanosoma nanum from Mongalla* Condition : Debilitated, intermittent fever, Admitted 6-6-22. Trypanosomes present in blood daily. Steadily lost condition in spite of rest and liberal diet.

On 14th, 15th and 16th June 1922 gave 5 grammes of Picric Acid daily intravenously (4 grammes in 60 c. c. alcohol absolute and 1 gramme in 90 c. c. of water). Trypanosomes were present on 17 6-22.

On the 25th. and 28th. June, and 1st. July 1922 the following injections were given 3 \ grammes of Picric Acid (3 grammes in alcohol and 4 gramme in water), and 50 c. c. of 2% solution of Tartar Emetic.

That is, a course of 3 doses every third day. Daily observations on the blood were carried out for three months. Trypanosomes did not reappear.

The horse was branded with a UJ"' on the left shoulder and kept under observation in the Hamla lines at Khartoum.

On 20th October, 1923, i.e. 16 months after the treatment, the animal was in good condition, and examination of the blood was negative. Case (ii).

Mule No. 203. Grey. 5 years old. 13.3. From Bahr-el Gbazal. Emaciated and very weak. Intermittent fever. Admitted 17th June, 1922, and kept under observation till 25th June, 1922. Trypanosomes present daily, and animal getting weaker in spite of rest and liberal diet. -Natural infection with Trypanosoma nanum,